Subjects with preclinical Alzheimer’s disease had a larger foveal avascular zone and decreased inner foveal thickness compared with subjects without preclinical Alzheimer’s disease.

The case-controlled study included 58 eyes from 30 participants who underwent positron emission tomography and/or cerebral spinal fluid testing to determine biomarker status. Measurements such as retinal nerve fiber layer thickness, inner and outer foveal thickness, and foveal avascular zone were taken with OCT angiography (OCTA).

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