SARS-CoV-2 and Ocular surface
Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface. SARS-CoV-2 uses the angiotensin converting enzyme 2 (ACE2) as a receptor for cell entry, with transmembrane protease serine type 2 (TMPRSS2) responsible for cleaving the spike protein to fuse […]
Varenicline Nasal Spray Efficacious for Dry Eye
Experimental Phace III trial suggest, Varenicline is effective for Dry eye when squirted nasally. According to Dr Michael Raizman, MD, an associate professor of ophthalmology at Tufts University School of Medicine in Boston, Massachusetts, it stimulates trigeminal nerve nasally causing patient to sneeze and simultaneously eyes to tear. Unlike conventional dry eye treatment, Oyster Point’s […]
OCT-A and Amblyopia
Optical coherence tomography(OCT-A) seems promising in diagnosing and understanding the pathogenesis of amblyopia, ideal in children, offering an objective tool on top of visual acuity to guide treatment plans. A population based cohort study (30 children with amblyopia and 1045 controls) confirms the presence of retinal microvasculature abnormalities in amblyopic eyes, which opens the […]
Young Myopes and Atropine – Treat Them Right
With COVID-19 pandemic outbreak and reduced outdoor time for children, the risk for childhood myopia has increased many folds. Young children (around 6 years of age) require higher concentrations (0.05%) of atropine to achieve similar reductions in myopia progression as older children (8-10 years of age) on lower concentrations (0.025% or 0.01%), since myopia […]
Enteral Lipid Supplementation and Retinopathy of Prematurity
Enteral lipid supplementation with arachidonic acid (AA, 100 mg/kg/day) and docosahexaenoic acid (DHA, 50 mg/kg/day) in a ratio of 2:1 starting within three days of birth to premature infants born before 27 months reduces the risk of severe retinopathy of prematurity (ROP) to half as compared to infants without supplementation when treated till 40 weeks […]
Drug Abuse and Endophthalmitis
A U.S based study suggests a “high degree of suspicion” in patients with drug abuse leading to endogenous endophthalmitis as high as up to four folds, especially to recent trend of consuming intravenous opiates such as heroin. The morbidity and mortality rates from endogenous endophthalmitis worsens more with comorbidities like diabetes, malignancy, chronic kidney disease, Chronic […]
Trifocal-Lens Implant: A Spectacle Free Life
As per a Survey, Eighty percent of patients implanted with trifocal intraocular lenses(IOLs) never require spectacles as compared to one with monofocal IOLs( only 8%). Most patients require glasses after cataract surgery with monofocal IOL implantation and even multifocals affects contrast sensitivity with increased photic phenomena. The TFNTOO (Panoptix, Alcon, Fort Worth, TX) is the only […]
An Arrow in the Quiver: 3D Cataract Surgery
The 3-D assisted vitreoretinal surgeries(N Genuity, Alcon)(Artveo 300, Zeiss) are in the news now for quite a while but the 3-D anterior segment procedures, yet, need some more futuristic considerations. There are certainly some obstacles to the use of simple microscope like: Microscope must be moved everytime for better visualisation, which makes it out of […]
“Durysta” Extended Release Bimatoprost Implant
The US Food and Drug Administration approved Allergan’s bimatoprost implant (Durysta) in March 2020, with a cost of around $1000. The bimatoprost implant, holds drug in a solid polymer matrix, biodegrades over time and maintained IOP as consistently as timolol maleate eye drops administered regularly at for at least 6 months, delivered better results as […]
Eye and Parkinson’s Disease
Parkinson’s disease can only be recognized once 80% of dopaminergic cells in the brain has degenerated and there is no biomarker for its diagnosis and no clinical method to diagnose its duration. A simple fundus examination of the eye studying the eye vasculature- the arrangement of vessels can promisingly detect Parkinson’s disease in early stage- […]